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KMID : 1098419990070030185
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Korean Journal of Medicinal Crop Science
1999 Volume.7 No. 3 p.185 ~ p.192
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Biological activities of Hovenia dulsis THUNB
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김영길/Kim, Young Gil
이미경/이진하/이현용/안상욱/김민회/Lee, Mi Kyoung/Lee, Jin Ha/Lee, Hyeon Yong/Ahn, Sang Wook/Hae, Kim Min
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Abstract
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Four different parts of Hovenia dulcis $T_{HUNB}$ 수식 이미지; fruit, bark, vessel area, fruit coat were extracted with water and ethanol. The ethanol extracts of bark, fruit coat and fruit were fractionized into diethyl ether, chloroform and aqueous partitions. Ethanol extract of fruit coat increased the activity of cathepsin B up to 55 %, which can enhance the alcohol dehydration in the liver. The ethanol extracts was more effective than water extracts against the growth of Hep3B, MCF7. The ethanol extracts of bark (0.5mg/ml) inhibited 90% the growth of MCF7. Each extracts and fractions (0.5mg/ml) did not show considerable cytotoxicity on HEL299. In overall, most of the fractions had similar effects to ethanol extracts; however, diethyl ether and chloroform fractions had higher bioactivity than ethanol extracts, but aqueous fraction.
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KEYWORD
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Hovenia dulcisTHUNB, cathepsin B, anti-cancer,, GST
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